Researchers stop the only current HIV vaccine efficacy trial

Vaccine did not prevent HIV infection: non-significant increase in infections in vaccine recipients

Gus Cairns
  Published: 26 April 2013

The US National Institute of Allergy and Infectious Diseases (NIAID) has announced that it is discontinuing the HVTN 505 HIV vaccine trial. This trial, which started in July 2009, has involved 2504 gay and transgender volunteers in 19 US cities. Since the successful conclusion of the RV144 vaccine trial in September 2009, HVTN 505, as a randomised, placebo-controlled phase IIb trial, has been the only ongoing HIV vaccine trial large enough to be a true test of vaccine efficacy.

NIAID stopped administering injections when the trial‘s independent data and safety monitoring board (DSMB) found during a scheduled interim review that there was no sign that the vaccine regimen was preventing HIV infection, nor any sign that it was reducing viral load among vaccine recipients who became infected with HIV.

http://www.aidsmap.com/page/2640732/

 

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